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KMID : 0388420000100010039
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Konkuk Journal of Medical Sciences
2000 Volume.10 No. 1 p.39 ~ p.48
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The Effect of the dose of Clarithromycin on the Eradication of Helicobacter pylori and the Healing of Ulcer in Peptic Ulcer Disease
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Park Eui-U
Park Bong-An
Lee Jae-Dong
Lee Jong-Hyuk
Kim In-Sook
Park Hyung-Seok
Jin Chun-Jo
Kim Sang-Yoon
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Abstract
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Helicobacter pylori is the major cause of histologic chronic gastritis and is strongly associated with peptic ulcer disease, gastriji cancer and lymphoma. Several recommendations for the management of the Helicobacter pylori infection have been developed. However, there has been no clear therapeutic regimen for the optimal treatment of Helicobacter pylori infection. This study was desinged to evaluate the eradication rate and the ulcer healing rate of the triple regimen with low-dose clarithromycin (0.5g/day) in peptic ulcer patients. Forty three patients with - gastric ulcer(n=15) and duodenal ulcer(n=28) were enrolled. The patients were treated either with omeprazole 20mg b.i.d, amoxicillin 0.5g b.i.d. and clarithromycin 250mg b.i.d. (low-dose regimen group, n=29) or with omeprazole 20mg b.i.d., amoxicillin
:V 1.0g b.i.d. and clarithromycin 0.5g b.i.d.(high -dose regimen group, n=14) for 2 weeks. After 4 weeks, the patients were evaluated for the eradication of Helicobacter pylori and the healing of ulcer. And gastritis scores according to the Sydney system were evaluated before and after 4 weeks from the end of the triple regimen. There was no significant difference in the eradication rate and the ulcer healing rate between the low-dose regimen group and the high-dose regimen group. In the low-dose regimen group, the mean initial scores of chronic inflammation and activity were decreased after the eradication of Helicobacter pylori. In conclusion, the low-dose triple regimen is as effective as the high-dose triple regimen on the eradication of Helicobacter pylori and the ulcer healing rate in peptic ulcer disease.
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KEYWORD
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Helicobacter pylori, eradication, peptic ulcer disease
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